Technology

Big cannabinoids, small package.

The cannabinoid sits inside an organogel nanoparticle carrier, protecting it from oxidation and degradation over time. Supplied in bulk to formulate with, or already carried in a hydrogel base. Every batch is characterised and documented.

10–20 nm
Average particle size
10% w/w
Cannabinoid content
10
Cannabinoids offered
2
Products
Size distributionDLS · intensity (%) vs d (nm)
100500
1
2
5
10
20
30
50
70
100
Diameter (nm)

What we make.

Both products contain the same particles. One is supplied in bulk undiluted form; the other is pre-formulated into a versatile hydrogel carrier. All natural, biologically derived ingredients.

Sapphire® Cannabinoid Nanoparticles™

Bulk nanoparticle API

Undiluted nanoparticle suspension, standardized at 10% cannabinoid content. Ten cannabinoid variants, usable in any water-compatible ingredient system; yours to formulate with.

Cannabinoid content10% w/w
FormatAqueous suspension
Variants10+ cannabinoids
Sapphire® Nanocrystal Hydrogel™

Transdermal hydrogel

The same nanoparticles in a hydrogel delivery system, for topical and transdermal application. Particles small enough to rapidly absorb from skin to bloodstream.

Cannabinoid content1% w/w
RouteTransdermal
CarrierHydrogel
CBD · CBG · CBC · CBN · CBT · CBDv · THCv · THCa · Δ8-THC · Prism™

Routes of administration

What it unlocks

Once a cannabinoid is water soluble and under 20 nm, the delivery routes once closed are now opened.

Oral

Beverages, syrups, capsules

Goes into water directly, with no emulsifier or co-solvent added at the blending stage. A drink stays clear and the dose stays uniform from the first pour to the last.

Cosmetic

Serums and emulsion-free actives

Water-compatible and optically transparent, so it can go into a clear serum or gel without clouding it or needing an oil phase.

Transdermal

Through the skin, or held on it

At this size the particle can cross the epidermis rapidly for direct absorption into blood. How far and how fast is a formulation choice: the hydrogel can be tuned to drive the dose through for systemic uptake, or to hold it at the surface for slower, local release.

Pulmonary

Nebulized inhalation

An aqueous suspension can be run through a standard nebulizer. There is no carrier oil to aerosolize, which is the usual obstacle for a lipophilic compound.

Intranasal

Nasal and olfactory

Fine enough to deposit on nasal mucosa, which is densely vascular and absorbs without passing through the gut. The olfactory region is the route studied for direct access to the central nervous system.

Pharmacokinetics

First-pass circumvention

Transdermal, nasal and pulmonary routes reach circulation without passing through the liver, so they avoid hepatic first-pass metabolism. Oral doses still pass through it, though lymphatic uptake of a particle this small reduces how much is lost.

Technology, Sapphire Nanomedicine