About

Democratizing nanomedicine.

Ever felt like CBD doesn't do anything? It's not because the research is thin. Cannabinoids are hydrophobic. They don't dissolve in water, so most of an oral, topical, or inhalable dose is never absorbed systemically. Nanoparticle delivery is the pharmaceutical answer to this, and it is normally very expensive to develop. Our particles carry 10% cannabinoid by weight at a uniform size under 20 nm, and we supply them in bulk at an affordable cost.

Absorption

Hydrophobic compounds absorb poorly

Blood is mostly water. A compound that will not dissolve in water cannot readily be absorbed into cells, so only a very small amount ends up being usable by the body. The limit is not the molecule, it is getting it into a form the body can actually use. This is not specific to cannabinoids: nanoparticle carriers are how the pharmaceutical industry handles poorly soluble drugs, often at outrageous costs to the consumer.

Drug loading

10% w/w drug loading

Drug loading is how much active drug a nano-carrier holds relative to its own mass. It is usually very low, around 1-5% on the high end, and it drops further as particles get smaller. Our particles hold 10% API by weight while staying at 10 to 20 nm, an innovation practically unheard of in the industry. This means the particles can travel to the hardest places to reach in the body, and deliver a heavy payload of active ingredient once there.

Particle size

Uniform, and under 20 nm

Standard CBD forms macro droplets greater than 1000 nm in the blood stream, so it's often simply too large to reach target destination. To illustrate: a tumor is like a dense sponge, and the pores of that sponge may be 40-50 nanometers wide. Our nanoparticles are 10 to 20 nm with less than 0.01% over 30. The small size allows the compound to permeate cells, tumors, and hard to reach places in the body prior to metabolization. This is the power of nanomedicine, so often gatekept by the medical elite.

Why it matters

Drug loading and particle size work against each other. Raising the loading tends to increase particle size, and holding the size down tends to reduce how much active the particle can hold. Achieving both at once is considered the holy grail of nanomedicine engineering, and it is what sets our research apart.

10–20 nm
Average particle size
10% w/w
Drug loading by weight

Formulation partners

Carried in finished products.

Brands formulating with our nanoparticles carry the distinct holographic seal of authenticity.

Partner brand
Partner brand
Partner brand
About, Sapphire Nanomedicine